Fish Oil & Eczema

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Eczema is a common skin condition characterized by an itchy, red rash. Many skin diseases cause somewhat similar rashes, so it is important to have the disease properly diagnosed before it can be treated.

Dietary changes that may be helpful: Eczema can be triggered by allergies.1 2 Most children with eczema have food allergies, according to data from double-blind research.3 A doctor should be consulted to determine if allergies are a factor. Once the trigger for the allergy has been identified, avoidance of the allergen can lead to significant improvement.4

It has been reported that when heavy coffee drinkers with eczema avoided coffee, eczema symptoms improved.5 In this study, the reaction was to coffee—not caffeine, indicating that some people with eczema may be allergic to coffee. People with eczema who are using a hypoallergenic diet to investigate food allergies should avoid coffee as part of this trial.

Nutritional supplements that may be helpful: Researchers have reported that people with eczema do not have the normal ability to process fatty acids, which can result in a deficiency of gamma-linolenic acid (GLA).6 GLA is found in evening primrose oil (EPO), borage oil, and black currant seed oil. Most double-blind research has shown that EPO overcomes this block and is useful in the treatment of eczema.7 8 9 An analysis of nine placebo-controlled trials reported that effects for reduced itching were most striking.10 Much of the research uses 12 pills per day; each pill contains 500 mg of EPO, of which 45 mg is GLA. Smaller amounts have been shown to lack efficacy.11 One study questioned the effectiveness of evening primrose oil for treating eczema;12 however, this negative study has been criticized.13

Borage oil has also been employed for eczema in open clinical trials, which showed reductions in skin inflammation, dryness, scaliness, and itch.14 However, a controlled study using 360 mg of GLA daily from borage in patients with eczema was unable to reproduce these results.15

Older reports using large amounts of vegetable oil (containing precursors to GLA) claimed some success,16 17 but these studies were not controlled and do not meet modern standards of research. As a result, it makes more sense to use GLA-containing oils (particularly EPO), rather than vegetable oil.

Ten grams of Fish oil providing 1.8 grams of EPA (eicosapentaenoic acid) per day were given to a group of eczema sufferers in a double-blind trial. After 12 weeks, those using the Fish oil experienced significant improvement.18 19 According to the researchers, Fish oil may be effective because it reduces levels of leukotriene B4, a substance that has been linked to eczema.20 The eczema-relieving effects of Fish oil may require taking ten pills per day for at least 12 weeks. Smaller amounts of Fish oil have been shown to lack efficacy.21

One trial reporting that Fish oil was barely more effective than placebo (30% versus 24% improvement) used vegetable oil as the placebo.22 As vegetable oil has previously been reported to have therapeutic activity, the apparent negative outcome of this trial should not dissuade people with eczema from considering Fish oil.

Although vitamin E at 400 IU per day has been reported in anecdotal accounts to alleviate eczema,23 research has not supported this effect.24 Moreover, rare cases of topical vitamin E potentially causing eczema have appeared.25 People with eczema should not expect vitamin E to be helpful with their condition.

In 1989, Medical World News reported that researchers from the University of Texas found that vitamin C, at 50–75 mg per 2.2 pounds of body weight, reduced symptoms of eczema in a double-blind trial.26 In theory, vitamin C might be beneficial in treating eczema by affecting the immune system, but further research has yet to investigate any role for this vitamin in people with eczema.

Are there any side effects or interactions? Refer to the individual supplement for information about any side effects or interactions.

Herbs that may be helpful: Licorice root, used either internally or topically, may help alleviate symptoms of eczema. A traditional Chinese herbal preparation, which includes licorice, has been successful in treating childhood and adult eczema in double-blind studies.27 28 The product, known as Zemaphyte, is currently under investigation in England. One or two packets of the combination is mixed in hot water and taken once per day. Topically, glycyrrhetinic acid, a constituent of licorice root, reduces the inflammation and itching associated with eczema.29 Some doctors suggest applying creams or ointments containing glycyrrhetinic acid three or four times per day. Licorice root may also be taken as a tincture in the amount of 2–5 ml three times daily.

Numerous other herbal preparations are used topically to relieve the redness and itching of eczema. A cream prepared with witch hazel and phosphatidylcholine has been reported to be as effective as 1% hydrocortisone in the topical management of eczema, according to one double-blind study.30

Topical applications of chamomile have been shown to be moderately effective in the treatment of eczema.31 32 One study found it to be about 60% as effective as 0.25% hydrocortisone cream.33

Other topical herbal preparations to consider based on traditional herbal medicine are calendula and chickweed creams. Calendula has anti-inflammatory properties, while chickweed is historically used to reduce itching.

Although burdock root is listed in traditional herbal books for the treatment of eczema, there is little evidence to support its use for this condition. It was used historically on the theory that supporting healthy liver function could help the body to remove potentially skin-damaging compounds from circulation.

Sarsaparilla may be beneficial as an anti-inflammatory based on historical accounts. Capsules or tablets should provide at least 9 grams of the dried root per day, usually taken in divided doses. Tincture is used in the amount of 3 ml three times per day.

In traditional herbal medicine, red clover is considered beneficial for all manner of chronic conditions, particularly those afflicting the skin. However, the mechanism of action and responsible constituents for red clover’s purported benefit in skin conditions is unknown. Wild oats has historically been used to treat a variety of skin conditions, including eczema, but it, too, is without scientific investigation.

Tannins, the main therapeutic component of oak bark, bind liquids, absorb toxins, and soothe inflamed tissues. For eczema characterized by oozing or weeping, oak is applied topically by first boiling 1–2 U.S. tablespoons (15–30 grams) of the bark for 15 minutes in 500 ml (2 cups) of water. After cooling, a cloth is dipped into the liquid and applied directly to the rash several times a day. The liquid prepared this way in the morning can be used throughout the day; unused portions should be discarded after that. This approach has been helpful in clinical practice34 but has yet to be scrutinized scientifically.

Are there any side effects or interactions? Refer to the individual herb for information about any side effects or interactions.

Checklist for Eczema

Ranking

Nutritional Supplements

Herbs

Primary

Evening primrose oil

 

Secondary

Fish oil (EPA/DHA)

Borage

Chamomile

Licorice

Witch hazel

Other

Vitamin C

Calendula

Chickweed

Oak

Oats

Red clover

Sarsaparilla

Information about the effects of a particular supplement or herb on a particular condition has been qualified in terms of the methodology or source of supporting data (for example: clinical, double blind, meta-analysis, or traditional use). For the convenience of the reader, the information in the table listing the supplements for particular conditions is also categorized. The criteria for the categorizations are: "Primary" indicates there are reliable and relatively consistent scientific data showing a health benefit. "Secondary" indicates there are conflicting, insufficient, or only preliminary studies suggesting a health benefit or that the health benefit is minimal. "Other" indicates that an herb is primarily supported by traditional use or that the herb or supplement has little scientific support and/or minimal proven health benefit.

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References:

1. Sampson HA, Scanlon SM. Natural history of food hypersensitivity in children with atopic dermatitis. J Pediatr 1989;115:23–7.

2. Burks AW, Mallory SB, Williams LW, Shirrell MA. Atopic dermatitis: clinical relevance of food hypersensitivity. J Pediatr 1988;113:447–51.

3. Niggemann B, Sielaff B, Beyer K, et al. Outcome of double-blind, placebo-controlled food challenge tests in 107 children with atopic dermatitis. Clin Exp Allergy 1999;29:91–6.

4. Atherton DJ. Diet and atopic eczema. Clin Allerg 1988;18:215–28 [review].

5. Veien NK, Hattel T, Justesen O, et al. Dermatoses in coffee drinkers. Cutis 1987;40:421–2.

6. Manku MS, Horrobin DF, Morse NL, et al. Essential fatty acids in the plasma phospholipids of patients with atopic eczema. Br J Dermatol 1984;110:643–8.

7. Schalin-Karrila M, Mattila L, Jansen CT, et al. Evening primrose oil in the treatment of atopic eczema: effect on clinical status, plasma phospholipid fatty acids and circulating blood prostaglandins. Br J Dermatol 1987;117:11–9.

8. Lovell CR, Burton JL, Horrobin DF. Treatment of atopic eczema with evening primrose oil. Lancet 1981;I:278 [letter].

9. Wright S, Burton JL. Oral evening-primrose oil improves atopic eczema. Lancet 1982;ii:1120–2.

10. Morse PF, Horrobin DF, Manku MS, et al. Meta-analysis of placebo-controlled studies of the efficacy of Epogam in the treatment of atopic eczema. Relationship between plasma essential fatty acid changes and clinical response. Br J Dermatol 1989;121:75–90.

11. Berth-Jones J, Graham-Brown RAC. Placebo-controlled trial of essential fatty acid supplementation in atopic dermatitis. Lancet 1993;341:1557–60.

12. Bamford JTM, Gibson RW, Renier CM. Atopic eczema unresponsive to evening primrose oil (linoleic and gamma-linolenic acids). J Am Acad Dermatol 1985;13:959–65.

13. Horrobin DF, Stewart C. Evening primrose oil in atopic eczema. Lancet 1990;I:864–5.

14. Landi G. Oral administration of borage oil in atopic dermatitis. J Appl Cosmetology 1993;11:115–20.

15. Borreck S, Hildebrandt A, Forster J. Borage seed oil and atopic dermatitis. Klinische Pediatrie 1997;203:100–4.

16. Cornbleet T. Use of maize oil (unsaturated fatty acids) in the treatment of eczema. Arch Dermatol Syph 1935;31:224–34.

17. Hansen AE, Knott EM, Wiese HF, et al. Eczema and essential fatty acids. Am J Dis Child 1947;73:1–18.

18. Bjørneboe A, Søyland E, Bjørneboe GE, et al. Effect of dietary supplementation with eicosapentaenoic acid in the treatment of atopic dermatitis. Br J Dermatol 1987;117:463–9.

19. Bjørnboe A, Søyland E, Bjørnboe GE, et al. Effect of n-3 fatty acid supplement to patients with atopic dermatitis. J Intern Med Suppl 1989;225:233–6.

20. Søyland E, Rajka G, Bjørneboe A, et al. The effect of eicosapentaenoic acid in the treatment of atopic dermatitis. A clinical Study. Acta Derm Venereol (Stockh) 1989;144(Suppl):139.

21. Berth-Jones J, Graham-Brown RAC. Placebo-controlled trial of essential fatty acid supplementation in atopic dermatitis. Lancet 1993;341:1557–60.

22. Søyland E, Funk J, Rajka G, et al. Dietary supplementation with very long-chain n-3 fatty acids in patients with atopic dermatitis. A double-blind multicentre study. Br J Dermatol 1994;130:757–64.

23. Olsen PE, Torp EC, Mahon RT, et al. Oral vitamin E for refractory hand dermatitis. Lancet 1994;343:672–3 [letter].

24. Fairris GM, Perkins PJ, Lloyd B, et al. The effect on atopic dermatitis of supplementation with selenium and vitamin E. Acta Derm Vernereol 1989;69:359–62.

25. Manzano D, Aguirre A, Gardeazabal J, et al. Allergic contact dermatitis from tocopheryl acetate (vitamin E) and retinol palmitate (vitamin A) in a moisturizing cream. Contact Dermatitis 1994;31:324.

26. Anonymous. Severe atopic dermatitis responds to ascorbic acid. Med World News 1989;April 24:41.

27. Sheehan MP, Atherton DJ. One-year follow up of children treated with Chinese medical herbs for atopic eczema. Br J Dermatol 1994;130:488–93.

28. Sheehan MP, Rustin MH, Atherton DJ, et al. Efficacy of traditional Chinese herbal therapy in adult atopic dermatitis. Lancet 1992;340:13–7.

29. Evans FQ. The rational use of glycyrrhetinic acid in dermatology. Br J Clin Pract 1958;12: 269–79.

30. Laux P, Oschmann R. Witch hazel – Hamamelis virgincia L. Zeitschrift Phytother 1993;14: 155–66.

31. Nissen HP, Blitz H, Kreyel HW. Prolifometrie, eine methode zur beurteilung der therapeutischen wirsamkeit kon Kamillosan®-Salbe. Z Hautkr 1988;63:184–90.

32. Aergeerts P, Albring M, Klaschka F, et al. Vergleichende prüfung von Kamillosan®-creme gegenüber seroidalen (0.25% hydrocortison, 0.75% flucotinbutylester) and nichseroidaseln (5% bufexamac) externa in der erhaltungsterpaie von ekzemerkrankungen. Z Hautkr 1985;60:270–7.

33. Albring M, Albrecht H, Alcorn G, Lüker PW. The measuring of the antiinflammatory effect of a compound on the skin of volunteers. Meth Find Exp Clin Pharmacol 1983;5:75–7.

34. Weiss RF. Herbal Medicine. Gothenberg, Sweden: Ab Arcanum and Beaconsfield: Beaconsfield Publishers Ltd, 1988, 328–9.

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